Oral magnesium prevents acetaminophen induced acute liver injury by modulating microbial metabolism ScienceDirect Tylenol (acetaminophen) may seem harmless But it could be working against your body's ability to heal. Depletes glutathione, your body's master antioxidant (Prescott, J Clin Invest, 1982) Glutathione is How Glutathione is Depleted from the Body Suzy Cohen, RPh offers natural remedies to help you feel better now! Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.