Collagen Supplements for Ehlers Danlos Syndrome and Hypermobility Ehlers Danlos syndrome (EDS) is a group of 13 related genetic (heritable) connective tissue disorders. EDS, particularly the hypermobile type (hEDS), frequently overlaps with Postural Orthostatic Tachycardia Syndrome (POTS) and Mast Cell Activation The Ehlers Danlos syndromes (EDS) are a group of heritable connective tissue disorders that vary in the ways they affect the body and in their genetic causes. Variants in the genes Ehlers Danlos Syndrome, Hypermobility, and Mast Cell Activation Syndrome: The Connection Dr. Tania Dempsey