Spotty lips. These are labial melanotic macules, kinda like freckles on the lips. They are mostly due to age and sun exposure, but sometimes they run in families and are associated with Figure 1 from Oral melanotic macule a case report. Semantic Scholar Pigmented Oral Lesions: Clues to Identifying the Potentially Malignant Consultant360 Peutz Jeghers syndrome: black spots localized in the perioral area. Download Scientific Diagram