Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Tylenol uses up the liver's stores of GLUTATHIONE. Glutathione is the body's most important ANTIOXIDANT. Acetaminophen C8H9NO2 CID 1983 PubChem Brittany Xavier here's two reasons why we don't personally use Tylenol or acetaminophen Instagram
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