How I permanently removed my freckles and moles Melanotan & PicoWay Laser Your body already makes a hormone that tells your skin to tan. Melanotan 2 is a synthetic peptide engineered to mimic that hormone but in a version that's more potent and Freckles develop when specific skin cells produce extra melanin in response to sunlight. When ultraviolet rays reach the skin, melanocytes release melanin to protect deeper layers from damage. In some people, certain Mole vs Freckle How to Tell & When to Get Checked