Methimazole induced hypothyroidism causes alteration of the REDOX environment, oxidative stress, and hepatic damage; events not caused by hypothyroidism itself Annals of Hepatology Understanding Hypothyroidism: Diagnosis and Treatment Glutathione is the body's primary internal antioxidant, made using the amino acid cysteine, and it helps protect cells from oxidative stress. Beyond detoxification, research shows glutathione is involved in thyroid hormone metabolism, 3 Thyroid Boosters: Red Light, Glutathione & Food Flow