Glutathione is such a critical soldier in our line of defense that our bodies make it themselves. We even have mechanisms that recycle and reuse it. But what happens when our toxic BRAFV600E in colorectal cancer reduces sensitivity to oxidative stress and promotes site specific metastasis by stimulating glutathione synthesis ScienceDirect Application of glutathione depletion in cancer therapy: Enhanced ROS based therapy, ferroptosis, and chemotherapy ScienceDirect Targeting the Vulnerability of Glutathione Metabolism in ARID1A Deficient Cancers ScienceDirect