Frontiers FOXO4 DRI regulates endothelial cell senescence via the P53 signaling pathway Most people learn about senescent cells from a podcast. I learned about them the hard way after pushing my body through the Grand Goals campaign and realizing that physical achievement doesn't mean A new class of drugs called senolytics works by hunting down and destroying senescent "zombie cells" that accumulate with age and drive wrinkles, weak bones, and organ decline. In an early human Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging: Cell