Sex differences in glutathione metabolism and acetaminophen toxicity Tylenol uses up the liver's stores of GLUTATHIONE. Glutathione is the body's most important ANTIOXIDANT. Tylenol and glutathione, actually explainedhere's the bullet points: * Lots of concern raised on social media re: glutathione depletion and acetaminophen use * Glutathione is used in the metabolism of acetaminophen and Metabolism of acetaminophen (paracetamol) in plantstwo independent pathways result in the formation of a glutathione and a glucose conjugate Environmental Science and Pollution Research Springer Nature Link