Alcohol and paracetamol are both processed through the liver. Paracetamol can form a toxic metabolite called NAPQI, which the body usually neutralises safely. But factors like heavy alcohol use, repeated dosing, fasting, Full article: The acetaminophen metabolite N acetyl p benzoquinone imine ( NAPQI) inhibits glutathione synthetase in vitro; a clue to the mechanism of 5 oxoprolinuric acidosis? NAPQI (N Acetyl 4 benzoquinone Imine) Acetaminophen Metabolite MedChemExpress Did you know that high doses of paracetamol can be toxic to your liver? Paracetamol, also known as acetaminophen, is a commonly used painkiller that can have harmful effects on the body