An oral melanotic macule is a harmless dark spot found on the lip, most often the lower lip, or inside the mouth, either on the gums, inside the cheek, or on the roof of the mouth. An oral melanotic Oral Melanotic Macule: Symptoms and Treatment Skinsight Labial Lentigo (labial melanotic macule) Cancer Therapy Advisor Oral Melanoma: A Rare but Aggressive Oral Cancer Oral melanoma is a rare and highly aggressive malignant tumor that develops from melanocytes within the oral mucosa. It most commonly affects the