Can paracetamol (acetaminophen) be administered to patients with liver impairment? Abstract Europe PMC Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Acetaminophen Toxicity: How Genetic Susceptibility Combines with Environmental Factors Tylenol's Impact on Glutathione and Liver Damage