Oral Melanotic Macule: Symptoms and Treatment Skinsight PDF] Oral melanoacanthoma and oral melanotic macule: a report of 8 cases, review of the literature, and immunohistochemical analysis. Semantic Scholar Melanotic macules of the tongue in a newborn Journal of the American Academy of Dermatology Melanosis coli** Melanosis coli is a benign, reversible condition characterized by brown black pigmentation of the colonic mucosa, most often due to chronic use of anthraquinone laxatives. The discoloration is caused