You can't out skincare internal depletion. Glutathione is one of the most important (and often overlooked) players in both skin clarity and overall wellness. When your body is overloaded, it shows up as: Imaging glutathione depletion in the rat brain using ascorbate derived hyperpolarized MR and PET probes Scientific Reports Glutathione Treatments 101: Part 1 The Mother of All Antioxidants BioDesign Wellness Center Identification of cytotoxic, glutathione reactive moieties inducing accumulation of reactive oxygen species via glutathione depletion ScienceDirect