Glutathione is such a critical soldier in our line of defense that our bodies make it themselves. We even have mechanisms that recycle and reuse it. But what happens when our toxic Does Glutathione IV and Vitamin Supplements with Glutathione Have Any Negative Side Effects? Glutathione deficiency alters the vitamin D metabolizing enzymes CYP27B1 and CYP24A1 in human renal proximal tubule epithelial cells and kidney of HFD fed mice ScienceDirect Role of glutathione transport processes in kidney function ScienceDirect