The pentose phosphate pathway in health and disease Nature Metabolism Explain how Inactivity or absence of Glucose 6 phosphate dehydrogenase ; a rate limiting enzyme in the Pentose phosphate pathway could lead to oxidative stress.* Pentose Phosphate Pathway Hexose Monophosphate Pathway Metabolism Glucose 1 phosphate promotes compartmentalization of glycogen with the pentose phosphate pathway in CD8+ memory T cells: Molecular Cell