Targeting the HGF MET axis in cancer: therapeutic promise for natural compounds ScienceDirect HGF c Met 1 integrin signalling axis induces tunneling nanotubes in A549 lung adenocarcinoma cells Life Science Alliance Dihexa is an experimental cognitive peptide that may help the brain build stronger connections between neurons instead of just temporarily boosting neurotransmitters like many nootropics do. It works through the HGF c Met pathway, What if neuroplasticity research targeted the HGF c Met pathway? Dihexa (PNB 0408) is an angiotensin IVderived peptide studied in preclinical models for its role in synaptogenesis and cognitive signaling mechanisms. Human data remains limited.