Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Acetaminophen (Paracetamol) Metabolites Induce Vasodilation and Hypotension by Activating Kv7 Potassium Channels Directly and Indirectly Arteriosclerosis, Thrombosis, and Vascular Biology Impact of medication on protein and amino acid metabolism in the elderly: the sulfur amino acid and paracetamol case Nutrition Research Reviews Cambridge Core IGF 1: Miracle Hormone or Health Hazard? Diet vs Disease
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