Synergy of GHKCu and hyaluronic acid on collagen IV upregulation via fibroblast and exvivo skin tests Jiang 2023 Journal of Cosmetic Dermatology Wiley Online Library How GHK Peptide Works Signaling GHK acts as a switch for skin repair: Interacts with adenosine receptors reduces inflammation Activates MAPK ERK, PI3K Akt, TGF pathways Stimulates fibroblasts & keratinocytes boosts collagen, elastin Biostetix Not everything that stimulates collagen is automatically beneficial in excess. GHK Cu is a powerful regenerative peptide but like many Instagram Intermediate Cu(II) Thiolate Species in the Reduction of Cu(II)GHK by Glutathione: A Handy Chelate for Biological Cu(II) Reduction Inorganic Chemistry