In RBCs, NADPH are produced exclusively via HMP shunt by the action of G6PD and are responsible to maintain membrane integrity preventing premature destruction. That is why G6PD deficient RBCs are Department of Genetic Engineering @ SRM University: Genetic Awareness Program on Glucose 6 Phosphate Dehydrogenase Deficiency Clinical associations and potential cellular mechanisms linking G6PD deficiency and atherosclerotic cardiovascular disease npj Metabolic Health and Disease Clinical Pharmacology & Toxicology Pearl of the Week
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