Disrupting Mitochondrial Pyruvate Uptake Directs Glutamine into the TCA Cycle away from Glutathione Synthesis and Impairs Hepatocellular Tumorigenesis: Cell Reports Glutamine reliance in cell metabolism Experimental & Molecular Medicine Glutathione VS L Glutamine: Supplement Brands Need To Know It turns out that T cells utilize quite a bit of glutamine to a) replenish TCA cycle intermediates ('anaplerosis') as well as to b) exchange for other amino acids.