A Practical Approach to Avoiding Drug Nutrient Depletions NBI Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Does Ibuprofen Deplete Glutathione? Understanding the Connection Cymbiotika CYMBIOTIKA Did you know that drugs like Tylenol and ibuprofen deplete the body's chief detoxifier, GLUTATHIONE? This is a BIG DEAL. Glutathione is essential not only for detox but also IMMUNE function,