Tylenol, Autism, and Leucovorin: What Parents Need to Know. Tylenol (acetaminophen) does not cause autism. The FDA, in its statement that there may be an association, confirmed that "a causal relationship has not been established, and studies of millions of children Acetaminophen Use During Pregnancy and Neurodevelopmental Risk: Biological Plausibility1 Journal of Obstetrics and Gynaecology Canada Evidence that acetaminophen triggers autism in susceptible individuals has been ignored and mishandled for more than a decade.