Gallbladder Guide Seeking Health Gallbladder Health 101: What It Does and How to Keep It Working Well Who's talking about this big problem? Low glutathione aa a causative big factor in gallstones. Why? Your biggest detoxification genes are the cytochrome P450 genes. These work very hard in eliminating most Frontiers Higher levels of oxidative balance score linked to lower risk of gallstones: findings from the 20172020 National Health and Nutrition Examination Survey