Combining Glutathione and Niacinamide for skin brightening can be extremely beneficial for your skin. Niacinamide helps reduce pigmentation and dark spots, whereas glutathione helps reduce melanin production, thereby lightening the dark spots 20 Most Asked Questions About Glutathione for Skin 25% Vitamin C + Glutathione Clinical Serum I've been using Niacinamide alone and it's just not working. Well this is why? Niacinamide is an amazing multipurpose ingredient but plays more of a support role and not a primary