Acetaminophen at low doses depletes airway glutathione and alters respiratory reflex responses Smith 2013 The FASEB Journal Wiley Online Library Amazon.com: JoySpring Liposomal Glutathione Supplement for Kids Supports Speech and Eye Contact 50 MG Antioxidant L Glutathione Drops 2 oz Liquid Detox Supplement : Everything Else Beware of Excessive Tylenol Pain And Spine Care Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.