Metabolism: The pentose phosphate pathway and G6PD deficiency (practice) Khan Academy glucose pathways and G6PD Caspershire Meta G6PD Deficiency Glucose 6 phosphate dehydrogenase deficiency X linked recessive disorder Leads to low NADPH, impairing glutathione regeneration RBCs are vulnerable to oxidative damage Pathophysiology: In G6PD deficiency: No Role of G6PD in managing oxidative stress Glutathione peroxidase Download Scientific Diagram