Since everyone is talking about Tylenol let's actually talk about Tylenol. No, it doesn't cause autism But here's what it can do: Deplete glutathione: one of your body's most Acetaminophen, a Therapeutic or an Extremely Toxic RemedyA Review Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. The Truth About Paracetamol and Glutathione Levels