How much nicotine is in JUUL? Vape vs Cigarette Nicotine: How Many 5% Vape Puffs Equal One Cig? One Juul pod contains the equivalent nicotine of 20 cigarettes a highly addictive amount. Today, some e cigs can contain more nicotine than *200 cigarettes.* Join us in sending a message to Nicotine formula used by e cigarette maker Juul is nearly identical to the flavor and addictive profile of Marlboro cigarettes : r science