Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health Old and New Analgesic Acetaminophen: Pharmacological Mechanisms Compared with Non Steroidal Anti Inflammatory Drugs Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. A new study out of John Hopkins University, funded by the NIH was just released citing that the use of Acetaminophen (Tylenol) during pregnancy increases the risk of ADHD and Autism